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MC lab 11 72dpi

Mercachem has optimized a Suzuki coupling reaction in the production of a fungicide. The reaction conditions were optimized by utilizing our unique in-house catalyst library. The original Suzuki reaction involved a high catalyst loading (1%) and the formation of a side product (10%).

This catalyst screening project was handled in three stages
(1 month, 1 FTE):

  • Side-product minimization to <0.1% by 400 variations in catalysts, bases, and solvents.
  • Optimization of the catalyst loading was lowered to <0.03% with >90% yield.
  • Successful verification on a 1 L scale with 0.01% catalyst loading.

The optimized reaction was successfully transferred to the customer’s pilot plant.