Proteolysis targeting chimeras (PROTACs) have recently received significant attention as a new modality for therapeutic intervention.
PROTAC molecules are typically around 1 kDa in size, and not seldom link together two molecules with mediocre physicochemical properties (high log P, low solubility). As a result, the synthesis, analysis, and purification of these compounds can be more challenging than that for traditional small-molecule ligands.
To address this challenge, we have developed a modular chemistry toolbox, in which different linking strategies are combined with optimized analytical routines. This approach allows for the rapid assembly of a comprehensive set of different PROTAC molecules for any new target. We can significantly speed up the development of your PROTAC program!
In addition, we are developing novel linkers that go beyond conventional polyethylene glycol (PEG) building blocks, with the goal of fine-tuning the properties of the resulting bivalent compound.