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Update COVID-19:

The COVID-19 situation is currently impacting most of the globe, including Asia, Europe and North America. At all MercachemSyncom sites, we follow the recommendations of the local competent authorities as they are released. We have established a series of contingency measures aimed at reducing risks for our employees, their families and the MercachemSyncom Operations. These measures are proactively being reassessed at regular intervals and adapted as deemed appropriate.

The MercachemSyncom team is united and determined to face the situation with the energy, strength and passion that constitute one of our hallmarks.

Patent lisdexamfetamine production improved enzymatic catalysis 72dpi

Enzymatic catalysis is a strong tool for the efficient improvement of synthetic production processes.

In collaboration with Noramco Inc. (US), scientists at Mercachem have invented a new production method for Lisdexamfetamine. The drug is used in the treatment of ADHD. Enzymes are used to catalyze the key step in the synthesis in a highly stereoselective manner. The new process is more cost effective and enables production of the drug with higher purity.

Dr. Phil Cox of Noramco commented: “The proposed use of enzymes as catalysts for the large scale production of Lisdexamfetamine has resulted in high conversions and stereo-selectivity, which was not possible using classical chemical methods.”

“Despite the many research activities in the field of biocatalysis currently, there still remains a large unexplored potential for the use of enzymes in the synthesis of active pharmaceutical ingredients,” said Dr. Göran Verspui, Director of Process Research. “Especially for large-scale applications, enzyme catalysts afford many advantages, such as increased product quality, simplified process operations, and reduced cost.”

Do you need an improved production process? Contact Mercachem to get in touch with our process research experts!


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