Scientists from Mercachem and the Radboud University in Nijmegen report on the synthesis of exciting, new, scaffolds for the European Lead Factory (ELF).
“We have prepared conformationally restricted, three-dimensional aminoketone scaffolds by applying continuous-flow photochemistry,” says Marjon Bolster, Senior Scientist at Mercachem.
“Convenient scaleup of the production of these scaffolds to more than 100 grams per day was achieved by the in-house fabrication of a high-throughput photoreactor.”
The article in Organic Process Research & Development also reports on approaches to further functionalize the scaffolds. The preparation of a 400-membered library is currently underway in our laboratories.