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Continuousflowphotochemistryappliedtoelfscaffoldsynthesis 72dpi

Scientists from Mercachem and the Radboud University in Nijmegen report on the synthesis of exciting, new, scaffolds for the European Lead Factory (ELF).

We have prepared conformationally restricted, three-dimensional aminoketone scaffolds by applying continuous-flow photochemistry,” says Marjon Bolster, Senior Scientist at Mercachem.

Convenient scaleup of the production of these scaffolds to more than 100 grams per day was achieved by the in-house fabrication of a high-throughput photoreactor.

The article in Organic Process Research & Development also reports on approaches to further functionalize the scaffolds. The preparation of a 400-membered library is currently underway in our laboratories.