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Leysin program highlights

 

Registration for the 13th Swiss Course on Medicinal Chemistry is open! 

This event will be held from October 7-12th, 2018 in its hometown, the scenic village of Leysin, Switzerland.

The organizers are proud to announce that many renowned experts in their respective research fields will contribute to the Swiss Course on Medicinal Chemistry as speakers and tutorial instructors. Attendees will receive authentic insights into emerging areas of small-molecule drug discovery from inspiring world-class leaders.

Among them is Dr. Karin Briner, Vice President and Global Head of Discovery Chemistry at the Novartis Institute for BioMedical Research (NIBR).  Dr. Briner will give the introductory lecture positioning small molecule drug discovery, i.e. the playground of practicing medicinal chemists, in today’s and tomorrow’s spectrum of therapeutic modalities.

As a world-class expert in Medicinal Chemistry, Dr. Nicholas A. Meanwell, Executive Director at Bristol-Myers Squibb, will provide a detailed report on truly successful drug discovery campaign pursued at BMS that yielded in an innovative breakthrough medicine. In addition to reporting on that success story, he will actively teach on the tactical application of  bio-isosteric concepts in Lead Finding and Optimization during hands-on tutorials, all attendees will participate in.

Dr. Peter Grootenhuis, Senior Director at Vertex Pharmaceuticals, will present a compelling story centred around the long and windy discovery route of a life-changing therapy, namely the Cystis Fibrosis drug Orkambi, consisting of ivacaftor and lumacaftor. This will be a breath-taking medicinal chemistry success story touching upon numerous interdisciplinary aspects such as phenotypic screening and personalized medicine.

The detailed aspects of thermodynamics and kinetics involved in the process of molecular recognition will be highlighted by a world-leading specialist in the field of biophysical, crystallographic and computational investigations of drug-target interactions, i.e. Prof. Dr. Gerhard Klebe, Univeristy of Marburg. He will highlight widely under-appreciated optimization parameters the medicinal chemistry community needs to get better acquainted with in the near future. This is a Must-Hear Topic for all practitioners in our scientific research field.

The strategic combination of high-resolution crystallography and Fragment-Based Lead Generation applied to one of the most challenging target families, i.e. G Protein-Coupled Receptors, will be introduced by a pioneer in the field, notably Dr. Jonathan Mason, Drug Design and Computational Chemistry Expert at Heptares Therapeutics. He is well known for burning off a firework of structure-based design teachings most relevant for our young colleagues in medicinal chemistry.

Dr. Andy Phillips, Chief Scientific Officer and President at C4 Therapeutics will introduce the concept of Targeted Protein Degradation in which synthetic conjugates of linked protein ligands are utilized to harness the innate power of the human organism to eliminate disease-causing proteins. This breakthrough technology offers a number of advantages for the treatment of cancer and other diseases, while avoiding traditional drug resistance.

 

Join us in Leysin!